646-ph

646-ph Controlling matter at the atomic level December 3, 2024 University of Bath Physicists are getting closer to controlling single-molecule chemical reactions -- could this shape the future of pharmaceutical research? Facebook Twitter Pinterest LinkedIN Email Controlling matter at the atomic level has taken a major step forward, thanks to groundbreaking nanotechnology research by an international team of scientists led by physicists at the University of Bath. This advancement has profound implications for fundamental scientific understanding. It is also likely to have important practical applications, such as transforming the way researchers develop new medications. Controlling single-outcome single-molecule reactions is now almost routine in research laboratories across the world. For example, over a decade ago, researchers from the technology giant IBM showcased their ability to manipulate individual atoms by creating A boy and his atom , the world's smallest movie. In the film, single molecules, consisting of two atoms bonded together, were magnified 100-million times and positioned frame-by-frame to tell a stop-motion story on an atomic scale. Achieving control over chemical reactions with multiple outcomes, however, has remained elusive. This matters because generally only some outcomes of a chemical reaction are useful. For instance, during drug synthesis, a chemical process that results in 'cyclisation' produces the desired therapeutic compound, however 'polymerisation', another outcome, leads to unwanted byproducts. Being able to precisely control reactions to favour desired outcomes and reduce unwanted byproducts promises to improve the efficiency and sustainability of pharmaceutical processes. Scanning tunnelling microscopy The new study, published today in the journal Nature Communications , set out to demonstrate for the first time that competing chemical reaction outcomes can be influenced by using the atomic resolution of a scanning tunnelling microscope (STM). Conventional microscopes use light and lenses to magnify specimens, allowing us to view them with the naked eye or a camera. However, when it comes to atoms and molecules, which are smaller than even the shortest wavelengths of visible light, traditional methods fall short. To explore these tiny realms, scientists turn to a scanning tunnelling microscope, which operates much like a record player. With a tip that can be as fine as a single atom, scanning tunnelling microscopes move across a material's surface, measuring properties such as electric current to map each point. However, rather than pressing the tip into the surface like a record player needle, the tip hovers just a single atom's width above it. When connected to a power source, electrons travel down the tip and make a quantum leap across the atom-sized gap. The closer the tip is to the surface, the stronger the current; the farther away it is, the weaker the current. This well-defined relationship between tip distance and current allows the microscope to measure and map the surface of the atom or molecule based on the electric current strength. As the tip sweeps across the surface, it builds a precise, line-by-line image of the surface, revealing details invisible to conventional light microscopes. Single-molecule reactions Using the atomic precision of a scanning tunnelling microscope, scientists can go beyond mapping the surface of a molecule -- they can both reposition single atoms and molecules, and influence and measure the likelihood of specific reaction pathways in individual molecules. Explaining, Dr Kristina Rusimova, who led the study, said: "Typically, STM technology is employed to reposition individual atoms and molecules, enabling targeted chemical interactions, yet the ability to direct reactions with competing outcomes remained a challenge. These different outcomes happen with certain probabilities governed by quantum mechanics -- rather like rolling a molecular die. "Our latest research demonstrates that STM can control the probability of reaction outcomes by selectively manipulating charge states and specific resonances through targeted energy injection." Dr Peter Sloan, senior lecturer in the Department of Physics and co-author of the study, said: "We used the STM tip to inject electrons into toluene molecules, prompting the breaking of chemical bonds and either a shift to a nearby site, or desorption. "We found that the ratio of these two outcomes was controlled by the energy of the electrons injected. This energy dependence allowed us to achieve control over the probability of each reaction outcome through the targeted "heating" of an intermediate molecular state, guided by precise energy thresholds and molecular barriers." PhD student Pieter Keenan, first-author on the research publication, said: "The key here was to maintain identical initial conditions for the test reactions -- matching the precise injection site and excitation state -- and then vary outcomes based solely on the energy of the injected electrons. "Within a single molecule's response to the energy input, the differing reaction barriers drive the reaction outcome probabilities. Altering only the energy input allows us, with high precision, to make a reaction outcome more likely than another -- in this way we can 'load the molecular dice'." Professor Tillmann Klamroth from Potsdam University in Germany, added: "This study combines advanced theoretical modelling with experimental precision, leading to a pioneering understanding of the reactions' probabilities based on the molecular energy landscape. This paves the way for further advances in nanotechnology." Looking ahead, Dr Rusimova said: "With applications in both basic and applied science, this advancement represents a major step toward fully programmable molecular systems. We expect techniques such as this to unlock new frontiers in molecular manufacturing, opening doors to innovations in medicine, clean energy, and beyond." The research is published in the journal Nature Communications. It was funded by The Royal Society, and the Engineering and Physical Science Research Council (EPSRC). Story Source: Materials provided by University of Bath . Note: Content may be edited for style and length. Journal Reference : Cite This Page :

Councillors against use of notwithstanding clause for encampments form 72-member coalitionFormer presidential candidate Nikki Haley was among the many users on social media condemning the Biden administration's decision to give $1 billion to Africa, arguing the United States is continuing to recover from hurricane season. President Joe Biden announced the aid on Tuesday during a visit to Angola, stating that doing so was “the right thing for the wealthiest nation in the world to do.” The financial aid , given in the wake of “historic droughts” in the African country, comes about two months after North Carolina was among several states that were hit by hurricanes in late September. “This is infuriating,” Haley wrote on X. “After pardoning his son and fleeing to Africa, Biden gives a BILLION of our tax dollars to rebuild homes in Africa when we still have people homeless from the hurricane! Completely tone deaf and insulting.” This is infuriating. After pardoning his son and fleeing to Africa, Biden gives a BILLION of our tax dollars to rebuild homes in Africa when we still have people homeless from the hurricane!Completely tone deaf and insulting. https://t.co/NrcZK2OJ71 — Nikki Haley (@NikkiHaley) Many other users on social media similarly condemned the aid, with Rep. Nancy Mace (R-SC) writing, “I beg your biggest pardon?”, in reposting the footage of Biden’s announcement. I beg your biggest pardon? https://t.co/Q4jFnbXkJH — Rep. Nancy Mace (@RepNancyMace) "With this administration, it's always America last," women's sports activist and Outkick host Riley Gaines wrote. With this administration, it's always America last https://t.co/PlKzVjwiaV — Riley Gaines (@Riley_Gaines_) "Remember those hurricanes that ravages Florida and North Carolina?" actor Kevin Sorbo wrote. "Those people got $750." Remember those hurricanes that ravaged Florida and North Carolina? Those people got $750. https://t.co/M8oBojxC3l — Kevin Sorbo (@ksorbs) "I really want this to be a typo," actress Justine Bateman wrote. I really want this to be a typo. #NorthCarolina https://t.co/qFly3KYpgB — Justine Bateman (@JustineBateman) "Joe Biden announces $1 BILLION in handouts to victims of AFRICAN natural disasters," musician Chad Prather wrote. "Meanwhile, hurricane victims in North Carolina are still struggling to survive. Can this America LAST clown show leave already?!?" Joe Biden announces $1 BILLION in handouts to victims of AFRICAN natural disasters Meanwhile, hurricane victims in North Carolina are still struggling to survive. Can this America LAST clown show leave already?!? pic.twitter.com/FaVVzw061k — Chad Prather (@WatchChad) CLICK HERE TO READ MORE FROM THE WASHINGTON EXAMINER The $1 billion to Africa comes right after the United States announced it would provide Ukraine with an additional $725 million in military weapons on Monday . Rep. Marjorie Taylor Greene (R-GA) deemed the move as “America LAST,” writing that the money ought to go toward North Carolina residents “who are homeless and sleeping in tents.” "America LAST again!!" Greene wrote. "This money should be spent helping the people in Western North Carolina who are homeless and sleeping in tents!" America LAST again!! This money should be spent helping the people in Western North Carolina who are homeless and sleeping in tents! https://t.co/VBek4hZuak — Rep. Marjorie Taylor Greene🇺🇸 (@RepMTG) On Sunday, Gov.-elect Josh Stein (D-NC) stated that he was "eager" to work with incoming President-elect Donald Trump on hurricane relief , citing the “unimaginable devastation” Hurricane Helene left earlier this year. Over 100 North Carolina residents were killed by the hurricane as of Nov. 26.

NEW YORK , Nov. 30, 2024 /PRNewswire/ -- Why: Rosen Law Firm, a global investor rights law firm, reminds purchasers of securities of iLearningEngines, Inc. (NASDAQ: AILE) between April 22, 2024 and August 28, 2024 , both dates inclusive (the "Class Period"), of t the important December 6, 2024 lead plaintiff deadline. So what: If you purchased iLearningEngines securities during the Class Period you may be entitled to compensation without payment of any out of pocket fees or costs through a contingency fee arrangement. What to do next: To join the iLearningEngines class action, go to https://rosenlegal.com/submit-form/?case_id=28305 or call Phillip Kim, Esq. toll-free at 866-767-3653 or email case@rosenlegal.com for information on the class action. A class action lawsuit has already been filed. If you wish to serve as lead plaintiff, you must move the Court no later than December 6, 2024 . A lead plaintiff is a representative party acting on behalf of other class members in directing the litigation. Why Rosen Law: We encourage investors to select qualified counsel with a track record of success in leadership roles. Often, firms issuing notices do not have comparable experience, resources, or any meaningful peer recognition. Be wise in selecting counsel. The Rosen Law Firm represents investors throughout the globe, concentrating its practice in securities class actions and shareholder derivative litigation. Rosen Law Firm achieved the largest ever securities class action settlement against a Chinese Company at the time. Rosen Law Firm was Ranked No. 1 by ISS Securities Class Action Services for number of securities class action settlements in 2017. The firm has been ranked in the top 4 each year since 2013 and has recovered hundreds of millions of dollars for investors. In 2019 alone the firm secured over $438 million for investors. In 2020, founding partner Laurence Rosen was named by law360 as a Titan of Plaintiffs' Bar. Many of the firm's attorneys have been recognized by Lawdragon and Super Lawyers. Details of the case: According to the lawsuit, during the Class Period, defendants made false and/or misleading statements and/or failed to disclose that: (1) iLearningEngines' "Technology Partner" was an undisclosed related party; (2) iLearningEngines used its undisclosed related party Technology Partner to report "largely fake" revenue and expenses; (3) as a result of the foregoing, iLearningEngines significantly overstated its revenue; and (4) as a result of the foregoing, defendants' positive statements about iLearningEngines' business, operations, and prospects were materially misleading and/or lacked a reasonable basis. When the true details entered the market, the lawsuit claims that investors suffered damages. To join the iLearningEngines class action, go to https://rosenlegal.com/submit-form/?case_id=28305 or call Phillip Kim, Esq. toll-free at 866-767-3653 or email case@rosenlegal.com for information on the class action. No Class Has Been Certified. Until a class is certified, you are not represented by counsel unless you retain one. You may select counsel of your choice. You may also remain an absent class member and do nothing at this point. An investor's ability to share in any potential future recovery is not dependent upon serving as lead plaintiff. Follow us for updates on LinkedIn: https://www.linkedin.com/company/the-rosen-law-firm , on Twitter: https://twitter.com/rosen_firm or on Facebook: https://www.facebook.com/rosenlawfirm/ . Attorney Advertising. Prior results do not guarantee a similar outcome. Contact Information: Laurence Rosen, Esq. Phillip Kim, Esq. The Rosen Law Firm, P.A. 275 Madison Avenue, 40th Floor New York, NY 10016 Tel: (212) 686-1060 Toll Free: (866) 767-3653 Fax: (212) 202-3827 case@rosenlegal.com www.rosenlegal.com View original content to download multimedia: https://www.prnewswire.com/news-releases/aile-deadline-aile-investors-have-opportunity-to-lead-ilearningengines-inc-securities-fraud-lawsuit-302318967.html SOURCE THE ROSEN LAW FIRM, P. A.Berlin confirmed plans to reform its legal framework make it a clear criminal offence to “facilitate the smuggling of migrants to the UK” as part of the agreement, the Home Office said. The Home Office said the move would give German prosecutors more tools to tackle the supply and storage of dangerous small boats. Both countries will also commit to exchange information that may help to remove migrant-smuggling content from social media platforms and tackle end-to-end routes of criminal smuggling networks as part of the deal. It comes ahead of the UK and Germany hosting the so-called Calais Group in London, which sees ministers and police from the two countries, alongside France, Belgium and the Netherlands, gather to discuss migration in Europe. Delegates are expected to agree a detailed plan to tackle people-smuggling gangs in 2025 at the meeting on Tuesday. Home Secretary Yvette Cooper said: “For too long organised criminal gangs have been exploiting vulnerable people, undermining border security in the UK and across Europe while putting thousands of lives at risk. “We are clear that this cannot go on. “Germany is already a key partner in our efforts to crack down on migrant smuggling, but there is always more we can do together. “Our new joint action plan with deliver a strengthened partnership with Germany, boosting our respective border security as we work to fix the foundations, and ultimately saving lives.” Nancy Faeser, German federal minister of the interior said: “We are now stepping up our joint action to fight the brutal activities of international smugglers. “This is at the core of our joint action plan that we have agreed in London. “It will help us end the inhumane activities of criminal migrant smuggling organisations. “By cramming people into inflatable boats under threats of violence and sending them across the Channel, these organisations put human lives at risk.” She said that “many of these crimes are planned in Germany” and the deal would help to counter “this unscrupulous business with even more resolve.” “This includes maintaining a high investigative pressure, exchanging information between our security authorities as best as possible, and persistently investigating financial flows to identify the criminals operating behind the scenes,” Ms Faeser said. Shadow home secretary Chris Philp said the announcement “doesn’t go far enough”. “The British public deserves a serious plan to control our borders and stop criminal gangs,” he said. “The National Crime Agency has said a deterrent is necessary to reduce the number of crossings, yet Labour scrapped the only deterrent before it even got started. “Meanwhile the numbers of illegal immigrants coming here continue to climb, with an 18% increase compared to the same period last year, with more than 20,000 people having made the crossing since the election.”Bronny set for G League road debut, sources saySKOPJE, North Macedonia (AP) — A political party in North Macedonia on Saturday demanded authorities ban social networks whose content incites violence and self-destructive behavior after several young people were seriously injured in connection with the popular “Superman challenge” on TikTok. Health authorities said at least 17 students, ages 10 to 17, were brought to hospitals in the capital Skopje and other towns over the past week with broken bones, contusions and bruises. The children were injured after being thrown into the air by their friends to fly like superheroes and get applause on the internet. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.

A tech company has signed a mammoth office deal in the South Bay.SANTA CLARA, Calif., Dec. 09, 2024 (GLOBE NEWSWIRE) -- AMD (NASDAQ: AMD) today announced that Tim Keating has joined the company as senior vice president, Government Relations and Regulatory Affairs, effective today. “Tim is a strong addition to lead our government relations team,” said Ava Hahn, AMD senior vice president, general counsel and corporate secretary. “As high-performance and AI chips play an increasingly larger role in our daily lives over the coming years, Tim’s extensive public policy expertise and deep understanding of regulatory landscapes will play a critical role expanding our engagements with key stakeholders.” Keating has decades of experience, including more than 14 years at Boeing as executive vice president, Government Relations. Before Boeing, he was the senior vice president of Global Government Operations at Honeywell International and served as special assistant to the President of the United States and as staff director for White House Legislative Affairs. He also held several positions with the U.S. House of Representatives. Keating received a bachelor’s degree in political science from the University of Scranton and an honorary doctorate of business administration from the University of South Carolina. About AMD For more than 50 years AMD has driven innovation in high-performance computing, graphics and visualization technologies. Billions of people, leading Fortune 500 businesses and cutting-edge scientific research institutions around the world rely on AMD technology daily to improve how they live, work and play. AMD employees are focused on building leadership high-performance and adaptive products that push the boundaries of what is possible. For more information about how AMD is enabling today and inspiring tomorrow, visit the AMD (NASDAQ: AMD) website , blog , LinkedIn and X pages. AMD, the AMD Arrow logo and combinations thereof, are trademarks of Advanced Micro Devices, Inc. Contact: Brandi Martina AMD Communications (512) 705-1720 Brandi.martina@amd.com Mitch Haws AMD Investor Relations 512-944-0790 mitch.haws@amd.com

North Macedonian political party demands ban on TikTok after at least 17 students injured

The AP Top 25 men’s college basketball poll is back every week throughout the season! Get the poll delivered straight to your inbox with AP Top 25 Poll Alerts. Sign up here . TULSA, Okla. (AP) — Michael Jacobs’ 19 points off of the bench helped lead Southern to a 70-66 victory over Tulsa on Saturday. Jacobs shot 7 of 15 from the field and 5 of 5 from the free-throw line for the Jaguars (4-4). Cam Amboree added 10 points while going 3 of 5 (2 for 3 from 3-point range) while they also had five rebounds. Derrick Tezeno shot 4 of 6 from the field to finish with 10 points. The Golden Hurricane (4-6) were led by Keaston Willis, who recorded 23 points and seven rebounds. Tyshawn Archie added 17 points, four assists and two blocks for Tulsa. Ian Smikle also had 11 points and eight rebounds. ___ The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .NEW YORK , Dec. 9, 2024 /PRNewswire/ -- To transform the landscape of algorithmic trading, global Fintech leader Broadridge Financial Solutions, Inc. (NYSE: BR ), today announced the launch of an innovative AI-powered algorithm insights service for NYFIX. Driven by real-time liquidity mapping, the service is designed to empower asset managers, hedge funds, and other buy-side firms to achieve unprecedented accuracy, seamless workflow integration, and proven cost-efficiency. "Algo traders will now have a quantitative, data-driven service to power critical trading decisions," said George Rosenberger, Head of NYFIX, Broadridge Trading and Connectivity Solutions. "By harnessing the power of AI and historical insights, we're giving our clients the tools they need to navigate complex markets with greater precision and confidence. This innovative solution not only optimizes trading strategies, but also reduces costs, making it an invaluable asset for the buy-side." This is the first and only solution of its kind, using advanced AI to leverage public and private data to understand the liquidity landscape, particularly potential dark fill location. This approach identifies the ideal algorithmic execution for any given order, reducing outliers to improve overall trading costs. Traders benefit from real-time alerts and in-trade analysis, allowing for in-flight adjustments to stay aligned with their objectives, ensuring optimal strategy selection throughout the trading process. The NYFIX service was developed based on decades of proven research from Jeff Alexander and Linda Giordano , whose pioneering work at Babelfish Analytics established the standard for understanding routing dynamics, analyzing venue liquidity, and optimizing algorithm selection. This collaboration brings together unique and proprietary trader-focused insights with the trusted and transformational technological capabilities and extensive distribution capacity of Broadridge, creating a powerful service to enhance the trader's ability to improve performance. Available to NYFIX Order Routing customers in the U.S. equities market, the solution's framework is built to expand rapidly across other asset classes and regions, with future plans to extend access to clients on other Order Routing Networks. About Broadridge Broadridge Financial Solutions (NYSE: BR ), is a global technology leader with the trusted expertise and transformative technology to help clients and the financial services industry operate, innovate, and grow. We power investing, governance, and communications for our clients – driving operational resiliency, elevating business performance, and transforming investor experiences. Our technology and operations platforms underpin the daily trading of more than $10 trillion of equities, fixed income and other securities globally. A certified Great Place to Work®, Broadridge is part of the S&P 500® Index, employing over 14,000 associates in 21 countries. For more information about us, please visit www.broadridge.com . Broadridge Contacts: Investors: Edings Thibault Head of Investor Relations, Broadridge [email protected] Media: Gregg Rosenberg Global Head of Corporate Communications [email protected] SOURCE Broadridge Financial Solutions, Inc.