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Former U.S. President Jimmy Carter dies at 100BGB-10188 is under clinical development by BeiGene and currently in Phase II for Non-Small Cell Lung Cancer. According to GlobalData, Phase II drugs for Non-Small Cell Lung Cancer have a 38% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. BGB-10188 overview BeiGene overview BeiGene is a biotechnology company. It specializes in the development and commercialization of immuno-oncology medicines to treat cancers. The company offers Zanubrutinib, a small molecule inhibitor to treat various blood cancers and Sonrotoclax, a small molecule Bcl-2 inhibitor for treating chronic lymphocytic leukemia. BeiGene also provides Tislelizumab (BGB-A317), a monoclonal antibody targeting solid tumors and hematologic cancer; and Pamiparib (BGB-290) against solid tumor malignancies. The company has operations in the US, Australia, Germany, Spain, Canada, Switzerland and Italy. BeiGene is headquartered in the Cayman Islands. For a complete picture of BGB-10188’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .
The AP Top 25 men’s college basketball poll is back every week throughout the season! Get the poll delivered straight to your inbox with AP Top 25 Poll Alerts. Sign up here . WILMINGTON, N.C. (AP) — Donovan Newby had 16 points in UNC Wilmington’s 76-61 victory over Appalachian State on Saturday night. Newby also added six assists for the Seahawks (5-2). Nolan Hodge added 15 points while shooting 6 for 10, including 2 for 5 from beyond the arc and had six rebounds. Harlan Obioha had 12 points and shot 5 of 5 from the field and 2 of 5 from the free-throw line. The Mountaineers (5-3) were led in scoring by CJ Huntley, who finished with 17 points. Jalil Beaubrun added 16 points and 11 rebounds for Appalachian State. Alonzo Dodd had 11 points. UNC Wilmington took the lead with 15:43 left in the first half and did not relinquish it. The score was 44-33 at halftime, with Hodge racking up 15 points. ___ The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .
Mobile wallets that allow you to pay using your phone have been around for well more than a decade, and over those years they’ve grown in popularity, becoming a key part of consumers’ credit card usage. According to a "state of credit card report" for 2025 from credit bureau Experian, 53% of Americans in a survey say they use digital wallets more frequently than traditional payment methods. To further incentivize mobile wallet usage, some credit card issuers offer bonus rewards when you elect to pay that way. But those incentives can go beyond just higher reward rates. In fact, mobile wallets in some ways are becoming an essential part of activating and holding a credit card. For example, they can offer immediate access to your credit line, and they can be easier and safer than paying with a physical card. From a rewards perspective, it can make a lot of sense to reach for your phone now instead of your physical card. The Apple Card offers its highest reward rates when you use it through the Apple Pay mobile wallet. Same goes for the PayPal Cashback Mastercard® when you use it to make purchases via the PayPal digital wallet. The Kroger grocery store giant has a co-branded credit card that earns the most when you pay using an eligible digital wallet, and some major credit cards with quarterly rotating bonus categories have a history of incentivizing digital wallet use. But again, these days it's not just about the rewards. Mobile wallets like Apple Pay, Samsung Pay and PayPal can offer immediate access to your credit line while you wait for your physical card to arrive after approval. Indeed, most major issuers including Bank of America®, Capital One and Chase now offer instant virtual credit card numbers for eligible cards that can be used upon approval by adding them to a digital wallet. Additionally, many co-branded credit cards — those offered in partnership with another brand — commonly offer instant card access and can be used immediately on in-brand purchases. Credit cards typically take seven to 10 days to arrive after approval, so instant access to your credit line can be particularly useful if you need to make an urgent or unexpected purchase. Plus, they allow you to start spending toward a card’s sign-up bonus right away. As issuers push toward mobile payments, a growing number of merchants and businesses are similarly adopting the payment method. The percentage of U.S. businesses that used digital wallets increased to 62% in 2023, compared to 47% the previous year, according to a 2023 survey commissioned by the Federal Reserve Financial Services. Wider acceptance is potentially good news for the average American, who according to Experian has about four credit cards. While that won’t necessarily weigh down your wallet, it can be hard to manage multiple cards and rewards categories at once. Mobile wallets offer a more efficient way to store and organize all of your workhorse cards, while not having to carry around ones that you don't use often. They can also help you more easily monitor your spending and rewards, and some even track your orders' status and arrival time. Plus, paying with a digital wallet offers added security. That’s because it uses technology called tokenization when you pay, which masks your real credit card number and instead sends an encrypted "token" that’s unique to each payment. This is unlike swiping or dipping a physical card, during which your credit card number is more directly accessible. And again, because a mobile wallet doesn't require you to have your physical cards present, there's less chance of one falling out of your pocket or purse. More From NerdWallet Funto Omojola writes for NerdWallet. Email: fomojola@nerdwallet.com . The article Activating Your Credit Card? Don’t Skip the Mobile Wallet Step originally appeared on NerdWallet.
SEOUL, South Korea (AP) — North Korean leader Kim Jong Un vowed to implement the “toughest” anti-U.S. policy, state media reported Sunday, less than a month before Donald Trump takes office as U.S. president. Trump’s return to the White House raises prospects for high-profile diplomacy with North Korea. During his first term, Trump met Kim three times for talks on the North's nuclear program. Many experts however say a quick resumption of Kim-Trump summitry is unlikely as Trump would first focus on conflicts in Ukraine and the Middle East. North Korea's support for Russia's war against Ukraine also poses a challenge to efforts to revive diplomacy, experts say. During a five-day plenary meeting of the ruling Workers’ Party that ended Friday, Kim called the U.S. “the most reactionary state that regards anti-communism as its invariable state policy.” Kim said that the U.S.-South Korea-Japan security partnership is expanding into “a nuclear military bloc for aggression." “This reality clearly shows to which direction we should advance and what we should do and how,” Kim said, according to the official Korean Central News Agency. It said Kim's speech “clarified the strategy for the toughest anti-U.S. counteraction to be launched aggressively” by North Korea for its long-term national interests and security. KCNA didn't elaborate on the anti-U.S. strategy. But it said Kim set forth tasks to bolster military capability through defense technology advancements and stressed the need to improve the mental toughness of North Korean soldiers. The previous meetings between Trump and Kim had not only put an end to their exchanges of fiery rhetoric and threats of destruction, but they developed personal connections. Trump once famously said he and Kim “fell in love.” But their talks eventually collapsed in 2019, as they wrangled over U.S.-led sanctions on the North. North Korea has since sharply increased the pace of its weapons testing activities to build more reliable nuclear missiles targeting the U.S. and its allies. The U.S. and South Korea have responded by expanding their military bilateral drills and also trilateral ones involving Japan, drawing strong rebukes from the North, which views such U.S.-led exercises as invasion rehearsals. Further complicating efforts to convince North Korea to abandon its nuclear weapons in return for economic and political benefits is its deepening military cooperation with Russia. According to U.S., Ukrainian and South Korean assessments, North Korea has sent more than 10,000 troops and conventional weapons systems to support Moscow's war against Ukraine. There are concerns that Russia could give North Korea advanced weapons technology in return, including help to build more powerful nuclear missiles. Ukrainian President Volodymyr Zelenskyy said last week that 3,000 North Korean troops have been killed and wounded in the fighting in Russia's Kursk region. It was the first significant estimate by Ukraine of North Korean casualties since the North Korean troop deployment to Russia began in October. Russia and China, locked in separate disputes with the U.S., have repeatedly blocked U.S.-led pushes to levy more U.N. sanctions on North Korea despite its repeated missile tests in defiance of U.N. Security Council resolutions. Last month, Kim said that his past negotiations with the United States only confirmed Washington’s “unchangeable” hostility toward his country and described his nuclear buildup as the only way to counter external threats.
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